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By
definition, the study of genomics has only become possible in the last
decade as the entire
genomes of organisms
were being deciphered. From its humble beginnings, the field of genomics
began in earnest in 1995 with the sequence of the first free-living organism,
a bacterium called Haemophilus influenzae containing 1.8 million base
pairs of DNA. Since then an explosion of sequence information has emerged
from
organisms as diverse as bacteria, yeast, flies, mice and plants. In April
2003, the largest and most ambitious project to date—the human genome—was
finally complete, with all 3 billion base pairs spelled out. This is
clearly a landmark scientific and technological achievement, but in many
ways,
it is merely the beginning of a long road of discovery that lies ahead.
Genomics aims to make sense of all this raw sequence data. We can now
begin to ask questions that were never possible before: What are all
the genes
turned on in cancer cells that are off in normal cells? How many targets
does a particular drug or herbicide have? What are all the genes that
make mice different from humans? Why do certain drugs work for some patients
but not others? Answers to these and many other important questions can
be discovered as vast amounts of sequence data are analyzed and interpreted
by genomic researchers from many different basic and applied disciplines. |
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The full value of genomics will only be realized using a multidisciplinary approach since it requires the integration of a diverse spectrum of fields such as genetics, biology, biochemistry, bioinformatics, epidemiology, computer science and engineering. Moreover, genomics has the potential to impact the health and welfare of society at all levels including drug discovery, patient care, crop protection and public policy. To address this challenge, UNC established the Carolina Center for Genome Sciences (CCGS) in August of 2001 with faculty appointments from 7 different academic units representing over 15 departments and disciplines. This group is made up of UNC faculty with well-established research programs, as well as recent hires from nationwide searches to recruit new, innovative scientists to complement existing faculty and to keep pace with the constantly evolving field of genomics. The Center has also invested significantly in state-of-the-art laboratories and core facilities, which are critical for making progress in this technology-driven endeavor. Furthermore, the CCGS is committed to training the next generation of basic scientists and clinicians in the genome sciences. To this end, several training programs have been established representing a variety of disciplines such as plant genomics, computational biology, and medical genetics. The CCGS also recognizes the importance of understanding the societal implications of genomic discoveries and has brought together a group of social scientists, physicians and legal experts with a common interest in healthcare education as well as public policy. In sum, the CCGS encompasses an impressive array of faculty members,
facilities, training programs and outreach efforts. UNC-Chapel Hill is
dedicated to making significant advances in basic genomic research, as
well as translating these discoveries to improving healthcare, education
and society. |
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Terry
Magnuson, PhD – Director Jennifer Brennan, PhD – Associate Director for Research Jeff Dangl,
PhD – Faculty
Associate Director Jim
Evans, MD, PhD – Faculty Associate Director Cara Marlow - Training Programs Administrator Sausyty
Hermreck - Training Programs Coordinator
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