Pardo Manuel Genome Dynamics Center

NIH/NIGMS recently announced the funding of two new Systems Biology centers, bringing the total to seven centers whose long-term mission is “to develop new strategies and tools for studying the complexity of biological systems.” CCGS faculty member Fernando Pardo Manuel de Villena is an investigator on one of these new centers, led by Gary Churchill at The Jackson Laboratory. Dr. Churchill’s Genome Dynamics Center will receive about $15.1 million over 5 years to learn how patterns of genetic variation emerge and persist over time. By creating a collection of genetic information from a set of more than 200 inbred strains of mice, the research team will study expression patterns to identify co-expressed genes, examine how these patterns evolved, and investigate how the overall genome organization affects phenotype.

Dr. Pardo Manuel de Villena will be leading a genotyping effort to identify clusters of 4-5 markers of diverse evolutionary origin in 500 bp segments spaced at 100 kb intervals across the mouse genome. The resulting data will 1) provide considerably improved maps of linkage disequilibrium domains and networks, 2) provide insight into the evolutionary forces responsible for the assembly of these domains and networks, 3) improve the reliability/resolution of in silico QTL mapping, 4) identify and map historical recombination events and relate these to current maps of recombination hotspots, and 5) address several basic evolutionary questions for which the genus Mus is exceptionally well-suited.

NIGMS press release




			April 10, 2006 NIH/NIGMS recently announced the funding of two new Systems Biology centers, bringing the total to seven centers whose long-term mission is “to develop new strategies and tools for studying the complexity of biological systems.” CCGS faculty member Fernando Pardo Manuel de Villena is an investigator on one of these new centers, led by Gary Churchill at The Jackson Laboratory. Dr. Churchill’s Genome Dynamics Center will receive about $15.1 million over 5 years to learn how patterns of genetic variation emerge and persist over time. By creating a collection of genetic information from a set of more than 200 inbred strains of mice, the research team will study expression patterns to identify co-expressed genes, examine how these patterns evolved, and investigate how the overall genome organization affects phenotype. Dr. Pardo Manuel de Villena will be leading a genotyping effort to identify clusters of 4-5 markers of diverse evolutionary origin in 500 bp segments spaced at 100 kb intervals across the mouse genome. The resulting data will 1) provide considerably improved maps of linkage disequilibrium domains and networks, 2) provide insight into the evolutionary forces responsible for the assembly of these domains and networks, 3) improve the reliability/resolution of in silico QTL mapping, 4) identify and map historical recombination events and relate these to current maps of recombination hotspots, and 5) address several basic evolutionary questions for which the genus Mus is exceptionally well-suited. NIGMS press release