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January 22, 2006
CCGS/Microbiology & Immunology faculty member Morgan Giddings was recently
awarded a three-year grant from the National Human Genome Research Institute
(NHGRI/NIH) to develop improved methods for genome annotation. Her
group along with Michael Brent’s group at Washington University in
St. Louis will enhance the capabilities of two existing computational tools,
GFS and TWINSCAN, by incorporating experimentally derived proteomics datasets
to re-annotate mammalian genomes. In the past, genome annotation has relied
on purely computational methods or cDNA information. Although these
approaches have been successful, they each have their own biases and limitations. Protein-based
gene finding is a distinct approach that is likely to lead to the discovery
of novel genes and different isoforms of known proteins that have been missed
with cDNA- or computationally-based approaches. Giddings CCGS webpage
Giddings
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