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A website developed by researchers at the Renaissance Computing Institute (RENCI) and the University of North Carolina at Chapel Hill will give biologists access to a new tool to help them create large, simulated sets of human genetic data that will enable more accurate studies on the relationship between genetic mutations and disease. The web–based tool, called HAP-SAMPLE, has already been used by several research groups in the U.S. and Europe during pre-release testing. It was developed through the Carolina Center for Exploratory Genetic Analysis, a collaborative project led by researchers from CCGS and RENCI. CCGS researchers involved in the development of HAP-SAMPLE include Fred Wright, Pat Sullivan, Kirk Wilhelmsen, Fei Zou, and Fernando Pardo-Manuel de Villena. Fred Wright is also the lead author of a recent publication describing this simulation tool: Simulating association studies: a data-based resampling method for candidate regions or whole genome scans. Wright FA, Huang H, Guan X, Gamiel K, Jeffries C, Barry WT, Pardo-Manuel F, Sullivan PF, Wilhelmsen KC, Zou F. Bioinformatics. 2007 Sep 4; [Epub ahead of print] HAP-SAMPLE website
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