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March 1, 2007 CCGS/Biology faculty member Jason Lieb was recently awarded a modENCODE grant from the National Human Genome Research Institute (NHGRI). The model organism ENCODE project (modENCODE) is a recent expansion of the original ENCODE project, launched in 2003, which aims to identify all functional elements in the human genome. The primary goal of modENCODE is to find all the functional sequence-based elements in the entire genomes of two very widely used multicellular model organisms with finished genome sequences, Caenorhabditis elegans and Drosophila melanogaster. Because of the nature of these two organisms as laboratory systems, the scope of modENCODE is somewhat broader than that of ENCODE. First, modENCODE addresses the entire genome of the target organisms, in contrast to the human ENCODE pilot project, which is limited to 1% of the genome. Second, it takes advantage of the experimental opportunities offered by model systems that are not possible with human or even other mammalian systems. Dr. Lieb has assembled an outstanding group of eight interdisciplinary investigators who plan on identifying all the DNA elements that govern chromatin function in C. elegans. This group is comprised of both experimental and computational biologists who are leaders in their respective fields. In addition to Dr. Lieb, members of the consortium include: Julie Ahringer (Wellcome Trust/UK), Abby Dernburg (Lawrence Berkeley National Laboratory), Arshad Desai (UC San Diego), Roland Green (NimbleGen Systems, Inc.), Xiaole Liu (Dana Farber Cancer Institute), Eran Segal (Weizmann Institute, Israel), and Susan Strome (Indiana University). Dr. Lieb is the lead principal investigator of this $7.2 million, four-year cooperative agreement (U01) from NHGRI, which is administered by CCGS. For more information:
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